Computer technology has made 'profound' [='major, significant'] changes in our lives.
His paintings have had a 'profound' effect/impact/influence on her own work.
Her books offer 'profound' insights into the true nature of courage.
(..) with a home And the freedom to do my work. I have tried to demonstrate My profound gratitude By championing the rights of the german people And by speaking truth to power. Four days ago, I appeared on this program (..)2015 TvShow: Homeland Title: A False Glimmer Season: 5 Episode 12