He's 'having a rough time (of it)'. = He's 'going through a rough time'. [=he is having a difficult time; his life has been difficult recently]
The project still has a few 'rough edges'. [=the project still has a few things that need to be changed or finished]
Don't 'be so rough on them' [=don't punish or criticize them so harshly] for making a mistake.
(..) But that is the absolute worst-case scenario. Just have the nurses do the stuff you're too chicken to do, which is everything, and if you have a really rough admission... Call you? No! Hide in the closet again. This is fun. - Nurse? - I'm a doctor. (..)2001 TvShow: Scrubs Title: My First Day Season: 1 Episode 1