People in ancient times assigned a particular 'significance' to the number seven.
This building should be preserved because of its historical 'significance'.
I failed to understand/grasp/appreciate the 'significance' of her remarks.
(..) November , . Unbelievable that old Biff could've chosen that particular date. It could mean that that point in time contains some cosmic significance... ...as if it were the temporal junction point of the entire space-time continuum... ...or it could just be an amazing coincidence. (..)1989 Back to the Future Part II