He stated, 'in substance' [='in essence', 'essentially'], that it is not his fault and he will not pay for damages.
These rumors have no 'substance'. = These rumors are 'without substance'. [=these rumors are not true]
Codeine is a 'controlled substance'. [=a drug that you need permission from a doctor to use]
(..) There're no cameras, hurry up. I've no time to waste. Go ahead. I'm gonna be sending you details of three people about to arrive in Europe. Each one is carrying a kilo of drugs. I need you to arrest them and collect the substance. I'll need it later. What form of these drugs in? Bars? Capsules? (..)2014 Lucy