He stated, 'in substance' [='in essence', 'essentially'], that it is not his fault and he will not pay for damages.
These rumors have no 'substance'. = These rumors are 'without substance'. [=these rumors are not true]
Codeine is a 'controlled substance'. [=a drug that you need permission from a doctor to use]
(..) You brought up Toblerone. I said it was better than that because I think it is. - Marzipan is candy. You like candy. - Marzipan is not candy. It is a unique substance unto itself, like Velveeta or plutonium. - You're not even going to try it? - I'll pass. - I'll try some. (..)2004 TvShow: Gilmore Girls Title: The Nanny and the Professor Season: 4 Episode 10