He stated, 'in substance' [='in essence', 'essentially'], that it is not his fault and he will not pay for damages.
These rumors have no 'substance'. = These rumors are 'without substance'. [=these rumors are not true]
Codeine is a 'controlled substance'. [=a drug that you need permission from a doctor to use]
(..) It's beautiful. The Vibranium atoms aren't just compatible with the tissue cells, they're binding them. And SHIELD never even thought... The most versatile substance on the planet and they used it to make a frisbee. Typical of humans. They scratch the surface and never think... ...to look within. (..)2015 Avengers: Age of Ultron