He stated, 'in substance' [='in essence', 'essentially'], that it is not his fault and he will not pay for damages.
These rumors have no 'substance'. = These rumors are 'without substance'. [=these rumors are not true]
Codeine is a 'controlled substance'. [=a drug that you need permission from a doctor to use]
(..) that thinks it's a game. He sat in our flat and he said these exact words to me... "All fairy tales need a good old-fashioned villain." The fifth substance, it's part of the tale. The witch's house. What? The glycerol molecule. PGPR! What's that? It's used in making chocolate. (..)2012 TvShow: Sherlock Title: The Reichenbach Fall Season: 2 Episode 3