His heart 'ached' [=he felt sad and sorry] for the children begging on the streets.
Symptoms of the flu include fever, general 'aches and pains', and sore throat.
She looked through the old pictures with a dull 'ache' in her heart.
(..) Truth is, I don't want to know. Some things are best left unsaid. I like to think it was something so beautiful... ...it can't be expressed in words... ...and makes your heart ache because of it. I tell you, those voices soared... ...higher and farther than anybody in a gray place dares to dream. (..)1994 The Shawshank Redemption
(..) ...you'd still be more of a man than anyone I've ever met. That's because you know what I can do with my little finger. -I have no idea. -But you're aching to find out. You're not going to let me in there, are you? You've got your armor back on. That's that. I have no armor left. (..)2006 Casino Royale
(..) What? Can you steer the ship? No. I just finished driver's ed. Yes, of course, I can steer a ship. Well... why don't we give her a stomach ache? We'll escape through the gut. It just might work if it doesn't kill us first. You steer, I'll shoot. All hands below deck! (..)2013 Percy Jackson: Sea of Monsters