This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) I don't need a visitor. SETH: You're not ill? No. I'm one of the doctors here. Are you in despair? I lost a patient. You did everything you could? I was holding his heart in my hand when he died. Then he wasn't alone. (..)1998 City of Angels
(..) Where doctors and nurses dedicate their lives... to that wonder which is a human being. ...an ever-changing challenge of love and hope, loneliness and despair. General Hospital on ABC. Doctors and nurses with first names and last names, and tragedies of their own. - Oh, I'm so sorry. - Excuse me. (..)2014 Annabelle
(..) astray, we have returned. Save for this. Jack! JACK: Not yet. We wait for the opportune moment. we found, but despaired of ever finding the last. When's that? When it's of greatest profit to you? May I ask you something? (..)2003 Pirates of the Caribbean: The Curse of the Black Pearl